A new species of deep-sea euryalid ophiuroid, Asteroschema sampadae is described from the continental margin off the southern tip of India. This species is distinguished from others in having scattered, distinctly conical epidermal ossicles throughout the aboral surface of the disc and arms and minute, scattered granular ossicles on the oral side. This is the fourth report of the genus Asteroschema from Indian waters (including Andaman & Nicobar Islands) and the first report of this genus from around the Indian peninsula since the report of Asteroschema flosculus from a coral bank off Nellore, Andhra Pradesh by Alcock in 1893.