Upper layer circulation, hydrography, and biological response of Andaman waters during winter monsoon are assessed based on the observations carried out onboard FORV Sagar Sampada during January 2009 and November–December 2011. Cool and dry air carried by the moderate winds (6 m/s) from north and northeast indicates the influence of northeast monsoon (NEM) in the area during the observation time. The characteristics of physical parameters and the water mass indicate that the southeastern side is dominated by the less saline water from South China Sea intruded through the Malacca Strait, whereas the northeast is influenced by the freshwater from Ayeyarwady-Salween river system. The western side of the Andaman and Nicobar Islands exhibits similar properties of Bay of Bengal (BoB) water as evidenced in the T-S relation. Circulation pattern is uniform for the upper 88 m and is found to be more geostrophic rather than wind driven. Magnitude of the current velocity varies between 100 and 900 mm/s in November–December 2011 with strong current (900 mm/s) near Katchal and Nancowry islands and 100 and 1000 mm/s in January 2009 recording strong current (1000 mm/s) near the Little Nicobar Island. The Andaman waters are observed as less productive during the season based on the satellite-derived surface chl-a (0.1–0.4 mg/m3) and column-integrated primary productivity (PP) (100–275 mgC/m2/d).